Okay, you’ve probably noticed that some Twitters who follow you are “pure” spammers. For example, they have “zero” updates with hundreds of followers.
I guess it’s acceptable to automate direct messages but sometimes you really need to filter out the good Twitters from pure spammers.
Here’s a couple great tips I found over at Twittercism on how to deal with there Twitter spammers:
2. Block them, use that “Block” button to block the spammer, this will also send a “red flag” to the Twitter spam handling department.
There a couple more tips but I will let you simply head over to Twittercism to check them out if you must.